API Droperidol For Pain EP CP CAS 548-73-2 GMP Antiemetic Drugs

Product Description

Droperidol API EP CP CAS No. 548-73-2

International non-proprietary name: Droperidol
National approved name : Droperidol
Chemical name: 1-[1-[4-(4-Fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl]-1,3-dihydro-2H-benzimidazol-2-one
Additional chemical name: N/A
CAS:548-73-2

Molecular formula:C₂₂H₂₂FN₃O₂

Molecular Weight:379.4

Melting point:: 148℃～153℃

Solubility:

Freely soluble in chloroform, slightly soluble in alcohol and ethyl acetate practically insoluble in water.

Identification—
A: Infrared Absorption 197K.
B: Ultraviolet Absorption 197U—
Solution: 15 µg per mL.
Medium: 0.1 N hydrochloric acid in isopropyl alcohol (1 in 10).
Loss on drying 731— Dry it in vacuum at 70 for 4 hours: it loses not more than 5.0% of its weight.
Residue on ignition 281: not more than 0.2%.
Limit of 4,4¢-bis[1,2,3,6-tetrahydro-4-(2-oxo-1-benzimidazolinyl)-1-pyridyl]butyrophenone— Dissolve about 30.0 mg of the sample in 70 mL of isopropyl alcohol in a 100-mL volumetric flask. Add 10.0 mL of 0.1 N hydrochloric acid, dilute with isopropyl alcohol to volume, and mix. The absorptivity of the solution in 1-cm cells at the wavelength of maximum absorbance at about 330 nm, with a suitable spectrophotometer, using a 1 in 10 solution of 0.1 N hydrochloric acid in isopropyl alcohol as the blank, is not more than 0.7 (equivalent to limit of 1.5%).
Assay— Dissolve about 240 mg of Droperidol, previously dried and accurately weighed, in 50 mL of glacial acetic acid, add p-naphtholbenzein TS, and titrate with 0.1 N perchloric acid VS. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 37.94 mg of C22H22FN3O2.