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API Amidotrizoic Acid Dihydate USP EP Diatrizoate Meglumine CAS No 50978-11-5

Minimum Order Quantity : 50 kg Packaging Details : 50kg in a fiber drum
Delivery Time : 30 days Payment Terms : T/T, L/C
Supply Ability : 50000 kg per year
Place of Origin: China Brand Name: LIBANG
Certification: Chinese GMP

Detail Information

Quality Specification: USP, EP, CP Dossier: DMF Available
Batch Size: Approx. 500kg Storage: Store At Room Temperature.
Delivery: Prompt Origin: China
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API Amidotrizoic Acid Dihydate

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Amidotrizoic Acid Dihydate USP

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Diatrizoate Meglumine CAS No 50978-11-5

Product Description

Amidotrizoic Acid Dihydate API EP CAS No.50978-11-5

 

International Nonproprietary Names (INN): Diatrizoic Acid

Compendial name, given in EP: Amidotrizoic Acid

Compendial name, given in CP: Diatrizoic Acid

USAN name: Diatrizoic Acid

Chemical name: Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-.3,5-Diacetamido-2,4,6-triiodobenzoic acid

Description: White powder.

Solubility: Very slightly soluble in water; soluble in ammonia solution or sodium hydroxide solution.

Fuction: Amidotrizoic Acid Dihydate is used for producing the radiopaque contrast agent for intravascular use named as Diatrizoate Meglumine and Diatrizoate Sodium Injection or Diatrizoate Meglumine Injection.

 

Mechanism of action
Diatrizoate is an iodine-containing X-ray contrast agent. Iodated contrast agents were among the first contrast agents developed. Iodine is known to be particular electron-dense and to effectively scatter or stop X-rays. A good contrast agent requires a high density of electron-dense atoms. Therefore, the more iodine, the more "dense" the x-ray effect. Iodine based contrast media are water soluble and harmless to the body. These contrast agents are sold as clear colorless water solutions, the concentration is usually expressed as mg I/ml. Modern iodinated contrast agents can be used almost anywhere in the body. Most often they are used intravenously, but for various purposes they can also be used intraarterially, intrathecally (the spine) and intraabdominally - just about any body cavity or potential space.

 

 

TEST SPECIFICATION RESULT
Appearance White, odorless powder

Conforms

Identification (1) It responds to the Thin-Layer Chromatographic Identification Test Conforms
(2) Positive reaction Conforms
Water 4.5%~7.0% 5.6%
Residue on ignition NMT0.1% 0.06%
Iodine and iodide NMT 0.02% of iodide

 

Conforms

Heavy metals NMT 0.002% Conforms
Free aromatic amine NMT 0.05% 0.008%
Ethyl alcohol NMT 0.5% Not detected
Acetic acid NMT 0.5% Not detected
Bacterial endotoxins NMT 1.5 EU/g <1.5 EU/g
Microbial Limit Total aerobic microbial count: <1000 cfu/g Conforms
Total yeast and molds count: <100 cfu/g Conforms
Assay 98.0%~102.0%(Calculated on the anhydrous basis) 99.2%

Xi'an Libang Pharmaceutical Co., Ltd. was established in 1996, It is a professional Manufacture specializing in pharmaceutical raw materials and Finished dosage form. The company has gathered a dedicated and professional sales and technical personnel. We have a marketing team with first-class efficiency and first-class service! Strong technical force, high quality and low price products, first-class marketing and after-sales service are your best choice!

API Amidotrizoic Acid Dihydate USP EP Diatrizoate Meglumine CAS No 50978-11-5 0

 

 

API Amidotrizoic Acid Dihydate USP EP Diatrizoate Meglumine CAS No 50978-11-5 1

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