Steroidal Antiestrogen Fulvestrant Anti Cancer Drug WC Avai 129453-61-8
Contact Person : Jimmy Tian
Phone Number : 86-18602905046
WhatsApp : +8618602905046
Minimum Order Quantity : | 100g | Packaging Details : | Inner package: double PE bag. Out package: 1-3kg in a Aluminum Tin |
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Delivery Time : | 30 days | Payment Terms : | T/T, L/C |
Supply Ability : | 100kg per year |
Place of Origin: | China | Brand Name: | LIBANG |
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Certification: | Chinese GMP and Written Confirmation for Exporting to EU |
Detail Information |
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Quality Specification: | USP | Dossier: | DMF Available |
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Batch Size: | Approx. 3kg | Storage: | Store At 2~8℃ |
Cert: | WC | Origin: | China |
High Light: | DMF Fulvestrant API,Fulvestrant API USP 129453-61-8,129453-61-8 Breast Cancer Medication |
Product Description
Fulvestrant API USP CAS No.129453-61-8 Anti-Cancer Drug Substance
Common Name: Fulvestrant
Manufacturer: Xian Libang Pharmaceutical Co., Ltd.
Mailing Address: No. 42, Fengchan West Road, Weiyang District, Xian, China 710086
Note to Physicians
Overdose Treatment: For current information about the treatment of overdose, consult a certified Regional Poison Control Center by
The quality of this API is featured as follow:
TEST | SPECIFICATION | |
Character | White powder,freely soluble in alcohol(95%). | |
Foreign Matter-IH |
The sample should be essentially free from black particles and foreign matter that can be observed on visual inspection. |
|
Identification A: IR | Consistent with spectrum of standard reference. | |
Identification B:
|
The retention time of the major peak in the chromatogram of the assay preaparation corresponds to that of the standard preparation. | |
Water | Not more than 0.5% | |
Related Compounds | ||
6-Keto-fulvestrant | Not more than 0.10% | |
Δ6,7-Fulvestrant | Not more than 0.10% | |
Fulvestrant sulfone | Not more than 0.15% | |
Fulvestrant extended | Not more than 0.15% | |
Fulvestrant sterol dimer | Not more than 0.15% | |
Any individual unspecified maximum impurity |
Not more than 0.10% | |
Total Impurities | Not more than 1.0% | |
Ratio of Isomers | ||
Fulvestrant A | 42.0%-48.0% | |
Fulvestrant B | 52.0%-58.0% | |
Residue of Solvents | ||
Tetrahydrofuran | Not more than 720ppm | |
Ethyl Acetate | Not more than 5000ppm | |
Dichloromethane | Not more than 600ppm | |
n-hexane | Not more than 290ppm | |
Ethanol | Not more than 5000ppm | |
Acetic acid
|
Not more than 5000ppm | |
Ethyl ether
|
Not more than 5000ppm | |
Heavy metals | Not more than 0.001% | |
Residue on ignition | Not more than 0.1% | |
Specific rotation | 108-115 at 365nm | |
Assay | 98%~102.0% |
Breast cancer
Fulvestrant is used for the treatment of hormone receptor positive metastatic breast cancer or locally advanced unresectable disease in postmenopausal women; it is given by injection.A 2017 Cochrane review found it is as safe and effective as first line or second line endocrine therapy.
It is also used to treat ER-positive, HER2-negative advanced or metastatic breast cancer in combination with palbociclib in women with disease progression after first-line endocrine therapy.
Due to the medication's having a chemical structure similar to that of estrogen, it can interact with immunoassays for blood estradiol concentrations and show falsely elevated results.This can improperly lead to discontinuing the treatment.
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