Steroidal Antiestrogen Fulvestrant Anti Cancer Drug WC Avai 129453-61-8
Contact Person : Jimmy Tian
Phone Number : 86-18602905046
WhatsApp : +8618602905046
| Minimum Order Quantity : | 100g | Price : | to be negotiated |
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| Packaging Details : | Inner package: double PE bag. Out package: 1-3kg in a Aluminum Tin | Delivery Time : | 25 days |
| Payment Terms : | T/T, L/C | Supply Ability : | 100kg per year |
| Place of Origin: | China | Brand Name: | LIBANG |
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| Certification: | Chinese GMP and Written Confirmation for Exporting to EU |
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Detail Information |
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| Quality Specification: | USP | Dossier: | DMF Available |
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| Batch Size: | Approx. 3kg | Storage: | Store At 2~8℃ |
| Certi: | WC | Pack: | Double PE Bag |
| High Light: | API Fulvestrant USP,Fulvestrant USP CAS No129453-61-8,129453-61-8 Anti Estrogen Drugs |
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Product Description
Fulvestrant
The Fulvestrant API has been exported to USA, Argentina, Brazil, Russia, Pakistan and India.
Xi'an Libang Pharmaceutical Co., Ltd. was established in 1996, It is a professional Manufacture specializing in pharmaceutical raw materials and Finished dosage form. The company has gathered a dedicated and professional sales and technical personnel. We have a marketing team with first-class efficiency and first-class service! Strong technical force, high quality and low price products, first-class marketing and after-sales service are your best choice!
Pharmacodynamics
Fulvestrant is an antiestrogen which acts as an antagonist of the estrogen receptor (ER) and additionally as a selective estrogen receptor degrader (SERD). It works by binding to the estrogen receptor and making it more hydrophobic, which makes the receptor unstable and misfold, which in turn leads normal processes inside the cell to degrade it.
In addition to its antiestrogenic activity, fulvestrant is an agonist of the G protein-coupled estrogen receptor (GPER), albeit with relatively low affinity (10–100 nM, relative to 3–6 nM for estradiol).
Formula: C32H47F5O3S
Synonym: n/f
Chemical Name: Estra-1,3,5(10)-triene-3,17-diol, 7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]-, (7alpha,17beta)-
CAS: 129453-61-8
RTECS Number: KG7623000
Chemical Family: Estrogen receptor antagonist
Therapeutic Category: Anti-estrogen; antineoplastic
Composition: Pure Material
| TEST | SPECIFICATION | |
| Character | White powder,freely soluble in alcohol(95%). | |
| Foreign Matter-IH |
The sample should be essentially free from black particles and foreign matter that can be observed on visual inspection. |
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| Identification A: IR | Consistent with spectrum of standard reference. | |
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Identification B:
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The retention time of the major peak in the chromatogram of the assay preaparation corresponds to that of the standard preparation. | |
| Water | Not more than 0.5% | |
| Related Compounds | ||
| 6-Keto-fulvestrant | Not more than 0.10% | |
| Δ6,7-Fulvestrant | Not more than 0.10% | |
| Fulvestrant sulfone | Not more than 0.15% | |
| Fulvestrant extended | Not more than 0.15% | |
| Fulvestrant sterol dimer | Not more than 0.15% | |
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Any individual unspecified maximum impurity |
Not more than 0.10% | |
| Total Impurities | Not more than 1.0% | |
| Ratio of Isomers | ||
| Fulvestrant A | 42.0%-48.0% | |
| Fulvestrant B | 52.0%-58.0% | |
| Residue of Solvents | ||
| Tetrahydrofuran | Not more than 720ppm | |
| Ethyl Acetate | Not more than 5000ppm | |
| Dichloromethane | Not more than 600ppm | |
| n-hexane | Not more than 290ppm | |
| Ethanol | Not more than 5000ppm | |
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Acetic acid
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Not more than 5000ppm | |
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Ethyl ether
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Not more than 5000ppm | |
| Heavy metals | Not more than 0.001% | |
| Residue on ignition | Not more than 0.1% | |
| Specific rotation | 108-115 at 365nm | |
| Assay | 98%~102.0% | |
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| Xi'an Libang Pharmaceutical Co., Ltd. |
| 17/F, Block E, Wangzuo International Plaza, No.1, Tangyan Road, Xi’an Hi-tech Zone, Shaanxi, P.R.China 710075 |
| 86-29-89527363 |
| jiangping@libang.com.cn |